Diaminoglyoxime Palladium (II) Chloride As An Efficient Catalyst for the Suzuki-Miyaura Cross-Coupling Reaction under Aerobic Conditions in H2O/EtOH Solution

Abstract

The preparation of diaminoglyoxime palladium (II) chloride (PdCl₂/DAG complex) and the use of this catalytic system in Suzuki-Miyaura cross-coupling reactions under aerobic and phosphine-free conditions in aqueous solutions is studied. Aryl halides, coupled with phenylboronic acids smoothly afford the corresponding cross-coupling products with excellent yields (80–98%). The catalytic system showed excellent performance for the Suzuki-Miyaura cross-coupling reaction of less reactive aryl chlorides with aryl boronic acids. The reaction conditions have been evaluated considering the effect of various parameters such as reaction time, temperature, amount of catalyst, amount of base and its nature and solvent