Synthesis of new heterocyclic compounds containing nitrogen, sulphur and study their biological activity

Abstract

Several substituted pyridines with brominated coumarin and with other substituents were achieved by condensing brominated coumarin IV with 4-methoxybenzaldehyde in basic solution forming α,β-unsaturated ketone II. Hantzsch reaction of this ketone with β-ketoester to provide precursor substituted pyridines. The Hantzsch reaction product was subjected to different reactions. The other targeted heterocyclic compound was obtained by reaction of α,β-unsaturated ketone II with hydrazine carbothioamide to give substituted pyrazole with brominated coumarin, also converted to different substituents. Structure analysis of the prepared heterocyclic compounds was confirmed by spectral data, elemental analysis. Antibacterial activity was screened towards some microorganism thus low and intermediate activity against Gram positive and negative bacteria were noted.