Synthesis of new heterocyclic compounds containing nitrogen, sulphur and study their biological activity

Authors

  • Basma Saad Baaiu Associate Prof., Department of Chemistry, Faculty Science/University of Benghazi, Benghazi
  • Mansour Abdelsalam Associate Prof., Department of Chemistry, Faculty Science/University of Benghazi, Benghazi,
  • Fateh Eltaboni Associate Prof., Department of Chemistry, Faculty Science/University of Benghazi, Benghazi,
  • Wafiyah Amhalhil Assistant Prof., Department of Chemistry, Faculty Science/Sirte University, Sirte

DOI:

https://doi.org/10.37591/etce.v8i3.6034

Keywords:

3-acetyl-7-bromo-2H-chromen-2-one, pyridines, pyrazolines, hiazolines and chalcone

Abstract

Several substituted pyridines with brominated coumarin and with other substituents were achieved by condensing brominated coumarin IV with 4-methoxybenzaldehyde in basic solution forming α,β-unsaturated ketone II. Hantzsch reaction of this ketone with β-ketoester to provide precursor substituted pyridines. The Hantzsch reaction product was subjected to different reactions. The other targeted heterocyclic compound was obtained by reaction of α,β-unsaturated ketone II with hydrazine carbothioamide to give substituted pyrazole with brominated coumarin, also converted to different substituents. Structure analysis of the prepared heterocyclic compounds was confirmed by spectral data, elemental analysis. Antibacterial activity was screened towards some microorganism thus low and intermediate activity against Gram positive and negative bacteria were noted.

References

R. Kenchappa, Yadav D. Bodke, A. Chandrashekar, Sandeep Telkar, K. S. Manjunatha, M. ArunaSindhe. Synthesis of some 2,6-bis(1-coumarin-2-yl)-4-(4-substitutedphenyl) pyridine derivatives as potent biological agents. Arabian Journal of Chemistry. 2013; 1-9p.

Rafat M. Mohareb, Nadia Y. Megally Abdo. Uses of 3-(2-Bromoacetyl)-2H-chromen-2-one in the Synthesis of Heterocyclic Compounds Incorporating Coumarin: Synthesis, Characterization and Cytotoxicity. Molecules. 2015; 20: 11535-11553.

Pravin O. Patil, Sanjay B. Bari, Sandip D. Firke, Prashant K. Deshmukh, Shailesh T. Donda, Dilip A. Patil. A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer’s disease. Bioorganic & Medicinal Chemistry. 2013; 21: 2434-2450.

Mohammad Asif. Overview of Diverse Pharmacological Activities of Substituted Coumarins: Compounds with Therapeutic Potentials. American Journal of Current Organic Chemistry. 2014; 1: 1-16.

Marwa Sayed El‐Gendy, Anhar Abdel‐Aziem, Abdou Osman Abdelhamid. Reactions and Antimicrobial activity of (3-(3-(4-Methoxyphenyl)acryloyl)-2H-Chromen-2-one. International Journal of Advanced Research. 2013; 1: 557-567.

Nada Elsharif, Mohamed Alnaily, Amnnah Loujanqi. Synthesis and Evaluation of Chalcone Derivatives and Schiff bases Derivatives as Antibacterial. Journal of Modern Chemistry & Chemical Technology. 2018; 9: 1-7.

Mirela Filipan-Litvić, Mladen Litvić, Ivica Cepanec, Vladimir Vinković. Hantzsch Synthesis of 2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-methoxyphenyl)-1,4-dihydropyridine; a Novel Cyclisation Leading to an Unusual Formation of 1-Amino-2-methoxycarbonyl-3,5-bis(o-methoxyphenyl)-4-oxa-cyclohexan-1-ene. Molecules. 2007; 12: 2546-2558.

Anhar Abdel-Aziem, Basma Saad Baaiu, Eslam R. El-Sawy. Reactions and Antibacterial Activity of 6-Bromo-3-(2-Bromoacetyl)-2H-Chromen-2-One. Polycyclic Aromatic Compounds. 2021; 1-9.

A. F. Zahoor1, S. Naheed, M. Irfan, S. Ahmad, M. N. Anjum, M. Yousaf. Advances in the synthesis and reactivity of acyl azides (2005-2015). AFINIDAD. 2018; 75: 228-238.

Anhar Abdel-Aziem, Basma S. Baaiu, Abdou O. Abdelhamid. Synthesis and Evaluation of Antimicrobial Activity of Some Novel Heterocyclic Compounds from 5-Bromosalicylaldehyde. J. Heterocyclic Chem. 2107; 54: 3471-3480.

Downloads

Published

2022-01-28

Issue

Vol. 8 No. 3 (2021)

Section

Articles

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.