Mechanistic and Catalytic Behavior of Os(VIII) for the Chlorpheniramine Maleate and Bromamine-B Redox System: A Kinetics Based Approach

Authors

  • Nirmala Vaz Department of Chemistry, Jyoti Nivas College Autonomous, Bangalore-560095, India
  • N. Divya Department of Chemistry, Jyoti Nivas College Autonomous, Bangalore-560095, India
  • P. Nagaraja Department of Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, India
  • A. S. Manjunatha Department of Chemistry, Bangalore University, Central College Campus, Bangalore-560001, India
  • Putta swamy Department of Chemistry, Bangalore University, Central College Campus, Bangalore-560001, India

Abstract

Chlorpheniramine maleate (CPM) is an important antihistamine agent. To the best of our knowledge there is no report in the literature about the oxidation of CPM with halogen + 1 oxidant from the stand point of its kinetics and mechanistic chemistry. Hence, a systematic kinetics and mechanistic study on the oxidation of CPM with bromamine-B (BAB) in the presence of NaOH and Os(VIII) catalyst has been carried out at 303 K. The reaction exhibits a first-order dependence of rate on [BAB]o and [Os(VIII)]. The order with respect to [CPM]o is zero, whereas it is fractional on [NaOH]. Activation parameters were evaluated. The stoichiometry of the reaction is 1:1 and the oxidation products were identified as (4-chlorophenyl)(pyridine-2-yl)methanol and 2-(dimethylamino)acetaldehyde from GC-MS analysis. The Os(VIII) catalyzed reaction is about four-fold faster than the uncatalyzed reaction. Based on the experimental results, possible reaction mechanism and kinetic model have been proposed.

 

Keywords: Chlorpheniramine maleate, Bromamine-B, Oxidation-kinetics, Os(VIII)
catalysis, mechanism

Downloads

Published

2019-04-15

Issue

Vol. 2 No. 1 (2015)

Section

Articles

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.