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An Efficient Synthesis of Annulated Novel Dihydropyridine Derivatives using Zeolite H-BEA and Zeolite BEA-SO3H

Kalpana C. Maheria, Manoj Kumar K. Rathod, Sunil R. Mistry, Suban K. Sahoo

Abstract


Modified zeolite (zeolite BEA-SO3H) was synthesized with intent to improve the surface area and Si/Al ratio by loading chlorosulphonic acid onto zeolite H-BEA. Parent and modified zeolite were characterized by variety of characterization techniques such as, ICP, FT-IR, XRD, TGA, NH3-TPD,BET surface area, etc. The catalytic applications of parent and modified zeolite H-BEA were demonstrated through the synthesis of novel quinoline and benzoquinoline substituted dihydropyridines (DHPs) via one pot Hantzsch cyclocondensation reaction. This method affords high percentage yield of DHPs (93%) within short reaction times. The effects of catalysts and substituent’s (different quinolines and benzoquinoline carbaldehydes) on the synthesis of DHPs were studied and related reaction mechanism was proposed

Keywords


Zeolite BEA-SO3H, Hantzsch reaction, MCRs, quinoline and benzoquinoline substituted dihydropyridines

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