Diaminoglyoxime Palladium (II) Chloride As An Efficient Catalyst for the Suzuki-Miyaura Cross-Coupling Reaction under Aerobic Conditions in H2O/EtOH Solution

Authors

  • Ali Reza Faraji Faculty of Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  • Hojat Veisi Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Iran
  • Ali Ghardashi Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Iran
  • Antonio Gil Department of Applied Chemistry, Los Acebos Building, Public University of Navarra, Campus of Arrosadia, E-31006, Pamplona, Spain

Keywords:

Suzuki-Miyaura, cross-coupling reaction, palladium catalyst, aryl halide, aryl boronic acid

Abstract

The preparation of diaminoglyoxime palladium (II) chloride (PdCl2/DAG complex) and the use of this catalytic system in Suzuki-Miyaura cross-coupling reactions under aerobic and phosphine-free conditions in aqueous solutions is studied. Aryl halides, coupled with phenylboronic acids smoothly afford the corresponding cross-coupling products with excellent yields (80–98%). The catalytic system showed excellent performance for the Suzuki-Miyaura cross-coupling reaction of less reactive aryl chlorides with aryl boronic acids. The reaction conditions have been evaluated considering the effect of various parameters such as reaction time, temperature, amount of catalyst, amount of base and its nature and solvent

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Published

2019-04-16

Issue

Vol. 1 No. 2 (2014)

Section

Articles

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