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The thermodynamic studies of 6-(4-chlorophenyl)-1, 2, 3, 4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile in 60% DMSO in the temperature range 298 to 313 K

Manoj R. Gaware

Abstract


Densities and viscosities of 6-(4-chlorophenyl)-1, 2, 3, 4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile have been measured at different concentration in 60% dimethyl sulphoxide (DMSO) in the temperature range 298 to 313 K. The John-Dole equation was used to determine the viscosity. Gibb’s free energy (∆G), entropy change (∆S) and enthalpy change (∆H) were evaluated from relative viscosity . The negative sign of ∆G and ∆H and positive sign of  ∆S indicates the spontaneity of reaction according to thermodynamics.


Keywords


Viscosity, 6-(4-chlorophenyl)-1, 2, 3, 4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile, thermodynamic parameters, Gibb’s free energy, enthalpy, entropy

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References


Clark J, Shahhet M, Korakas D, et al. Synthesis of thieno[2,3-D] pyrimidines from 4,6-

Dichloropyrimidine-5-carbaldehydes. Hetero. Chem., 1993; 30, 1065-2p.

Ogowva K, Yamawaki I, Matsusita Y, et al. Syntheses of substituted 2,4-dioxo-

thienopyrimidin-1-acetic acids and their evaluation as aldose reductase inhibitors. Eur. J

Med Chem., 1993; 28, 769-1p.

Tozkoparan B, Ertan M, Kelicen P, Demirdar, R. Synthesis and anti-inflammatory

activities of some thiazolo [3,2-a] pyrimidine derivatives. Farmaco, 1993, 54, 588-3p.

Aher J S, Gaware M R, Sawant A B, et al. Density, Viscosity of 2,4 dioxo pyrimidine

carbonitrile and 4-oxo-2-thioxo pyrimidine carbonitrile in 60 % aqueous DMSO at 308.15 K,

Res. World, 2016, 4(4), 120-4p.

Aher J S, Gaware M R, Lokhande D D. Densitometric and Viscometric studies

of 2, 4 dioxo pyrimidine carbonitrile and 4-oxo- 2-thioxo pyrimidine carbonitrile in 60

% aqueous DMSO at 298.15 K. Inter. J. Eng. Res. Gen. Sci., 2017, 5(4), 2017, 13-9p.

Gaware M R., Aher J S. Falkenhagen and Jones –Dole Coefficient studies of 2,4

dioxo pyrimidine carbonitrile and 4-oxo-2-thioxo pyrimidine carbonitrile in 60 % aqueous

DMSO at 303.15 K, Inter. J. Chem. Phy. Sci., 2018, 7(Spl Issue), 89-6p.

Sonar A N. The thermodynamic studies of substituted heterocyclic compound in 1,4

dioxane system in the temperature range 303 to 323 K, Ultra Chem., 2012, 8(1), 101-4.

Dhake R B. The thermodynamic studies of substituted heterocyclic compound in

ethanol system in the temperature range 303 to 323 K, Glo. J. Res.Ana., 5(2), 2016, 178-9p.

Gaware M R, Aher J S, Lokhande D D, et al . A simple and efficient one pot synthesis of 2,4

dioxopyrimidine carbonitrile and 4-oxo-2- thioxopyrimidine carbonitrile derivatives using

ammonium chloride under solvent free conditions, Ind. J. Chem.-B, 2017, 56(B) 09, 997-9p.




DOI: https://doi.org/10.37591/jopc.v8i2.4092

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