Characterization of Super Absorber Polymer for Using in Intestinal Dialysis

Abstract

Chronic kidney disease (CKD) is a worldwide public health problem with various adverse outcomes such as kidney failure and premature death. Many treatments for CKD have been introduced, but currently only kidney transplantation, hemodialysis, and peritoneal dialysis are used. Intestinal dialysis can be defined as a new technique to manage the end stage of kidney disease without the help of dialysis. The liquid in the intestines of kidney failure patients contains 70 grams of urea, 2.9 grams of creatinine and 2.5 grams of uric acid. As kidney function decreases, the concentration of these salts in the intestine increases. For this reason, it is possible to excrete toxins and waste materials such as creatinine, urea, uric acid and phosphate in the intestine much more than urine. One of these materials that can be used in intestinal dialysis are superabsorbent polymers. In the present study, the synthesis of SAP was optimized based on the properties of the networker to the primer. First, 7 grams of acrylamide, 5 grams of acrylic acid and cross-linking agent were combined together with a sufficient amount of distilled water for 4 hours in the presence of an ice bath. Then the temperature was slowly increased to 40°C and potassium hydroxide solution was used to neutralize the acrylic acid. At the end, the primer was added to the solution and the temperature was gradually increased to form a gel. Also, after forming the gel, divide it into smaller pieces and dry it under vacuum at 60°C for 3 days.